Detailed genome characterization reveals extensive RAG-mediated rearrangements in adult acute lymphoblastic leukemia subgroups

ABSTRACT: Acute lymphoblastic leukemia (ALL) is characterized by the accumulation of somatic genetic alterations in B- or T-lymphoid precursor cells eventually resulting in overt leukemia. We characterized somatic events associated with leukemic transformation by detailed genome-wide copy number analyses of 53 adult B-cell acute lymphoblastic leukemia (B-ALL) and, 20 adult T-cell ALL (T-ALL) cases by comparing to matched control remission specimens. Contrary the paediatric counterpart, adult ALL is scarcely researched in terms of genetic events. We initiated this study to examine whether there are differences in genetic events between paediatric and adult ALL and to observer whether these genetic lesions are driven by aberrant RAG activity. This submission of 53 adult B-ALL and 20 adult T-ALL, with

ORGANISM(S): Homo sapiens

SUBMITTER: Mathijs Sanders 

PROVIDER: E-MTAB-5036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress