Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from tumor tissue-derived long-term-cultured breast cancer stem cells


ABSTRACT: Here we established two tumor tissue-derived long-term-cultured breast cancer stem cells (BCSC). RNA extraction and microarray analysis total RNA from BCSC treating with G1, G15, or control (Ctrl) for 48 hr were extracted using Trizol Reagent. Important significant differences of cDNA genes were identified. (The G1-treated group was designed as \\"12\\", the control group was \\"11\\" (raw data: 11 and 12; processed data: BCSC-G1). Similarly, the G15-treated study group was defined as \\"14\\", the control group was \\"13\\" (raw data: 13 and 14; processed data: BCSC-G15).

INSTRUMENT(S): Affymetrix Genechip Command Console software, Trizol Reagent

ORGANISM(S): Homo sapiens

SUBMITTER: Xiaoti Lin 

PROVIDER: E-MTAB-5057 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells.

Lin Xiaoti X   Chen Weiyu W   Wei Fengqin F   Zhou Binhua P BP   Hung Mien-Chie MC   Xie Xiaoming X   Xie Xiaoming X  

International journal of cancer 20170316 11


The identification and understanding of the molecular network of cancer stem cells (CSCs) have had a profound impact on our view of carcinogenesis and treatment strategy. Unfortunately, a major problem is that serial passages of CSCs from clinical solid tumor specimens currently are not available in any lab, and thus, reported data are difficult to confirm and intensively interrogated. Here, we have generated two tumor tissue-derived breast CSC (BCSC) lines that showed prolonged maintenance over  ...[more]

Publication: 1/2

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