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ChIP-seq of ERG-bound regulatory elements in human and bovine vascular endothelial cells

ABSTRACT: In this study we set out to discover conserved orthologous ERG-bound gene regulatory elements in primary vascular endothelial cells isolated from human and cow

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Wilson

PROVIDER: E-MTAB-5148 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network.

Fish Jason E JE Cantu Gutierrez Manuel M Dang Lan T LT Khyzha Nadiya N Chen Zhiqi Z Veitch Shawn S Cheng Henry S HS Khor Melvin M Antounians Lina L Njock Makon-Sébastien MS Boudreau Emilie E Herman Alexander M AM Rhyner Alexander M AM Ruiz Oscar E OE Eisenhoffer George T GT Medina-Rivera Alejandra A Wilson Michael D MD Wythe Joshua D JD

Development (Cambridge, England) 20170523 13

The transcriptional pathways activated downstream of vascular endothelial growth factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand delta-like 4 (DLL4) in endothelial cells, we find that activation of the MAPK/ERK pathway mirrors the rapid and dynamic induction of <i>DLL4</i> transcription and that this pathway is required for <i>DLL4</i> expression. Furthermore, VEGF/ERK signaling induces phosphor ...[more]

PMID: 28536097

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