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MicroRNA profiling for prediction of chemoradiation efficacy in locally advanced head and neck squamous cell carcinoma

ABSTRACT: The predictive value of microRNAs for the efficacy of chemoradiation (CRTX) in locally advanced head and neck squamous cell carcinoma (HNSCC) was evaluated. Formalin-fixed, paraffin-embedded tumor material was collected from patients with locally advanced HNSCC treated within the ARO-0401 phase III trial with radiotherapy in combination with either 5-fluorouracil/cisplatin (CDDP-CRTX) or 5-fluorouracil/mitomycin C (MMC-CRTX).

ORGANISM(S): Homo sapiens

SUBMITTER: Anne-Katrin HeÃ

PROVIDER: E-MTAB-5198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma.

Hess Anne-Katrin AK Müer Annika A Mairinger Fabian Dominik FD Weichert Wilko W Stenzinger Albrecht A Hummel Michael M Budach Volker V Tinhofer Ingeborg I

European journal of cancer (Oxford, England : 1990) 20170326

<h4>Background</h4>The predictive value of microRNAs (miRNAs) in tumour cells and infiltrating immune cells for the efficacy of chemoradiation (CRTX) in locally advanced head and neck squamous cell carcinoma (HNSCC) was evaluated.<h4>Methods</h4>Formalin-fixed, paraffin-embedded tumour material was collected from patients with locally advanced HNSCC treated within the ARO-0401 phase III trial with radiotherapy in combination with either 5-fluorouracil/cisplatin (CDDP-CRTX) or 5-fluorouracil/mito ...[more]

PMID: 28347920

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