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Molecular analysis of clonal B cells in hepatitis C virus related-lymphoproliferation

ABSTRACT: Comparison of molecular pathways in clonal and non-clonal marginal zone B cells in Hepatitis C virus patients

ORGANISM(S): Homo sapiens

DISEASE(S): HCV-MC

SUBMITTER: Benjamin Terrier

PROVIDER: E-MTAB-521 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expansion of functionally anergic CD21-/low marginal zone-like B cell clones in hepatitis C virus infection-related autoimmunity.

Terrier Benjamin B Joly Florence F Vazquez Thomas T Benech Philippe P Rosenzwajg Michelle M Carpentier Wassila W Garrido Marlène M Ghillani-Dalbin Pascale P Klatzmann David D Cacoub Patrice P Saadoun David D

Journal of immunology (Baltimore, Md. : 1950) 20111114 12

Homeostasis of peripheral B cell subsets is disturbed during chronic hepatitis C virus (HCV) infection, leading to the occurrence of autoimmunity and B cell lymphoproliferation. However, mechanisms by which HCV causes lymphoproliferation remain controversial. We report in this article on the elevated number of clonal CD21(-/low)IgM(+)CD27(+) marginal zone (MZ)-like B cells, which correlates with autoimmunity and lymphoproliferation in HCV patients. We found an increase in autoreactive BCRs using ...[more]

PMID: 22084433

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