Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): HCV-MC
SUBMITTER: Benjamin Terrier
PROVIDER: E-MTAB-521 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Terrier Benjamin B Joly Florence F Vazquez Thomas T Benech Philippe P Rosenzwajg Michelle M Carpentier Wassila W Garrido Marlène M Ghillani-Dalbin Pascale P Klatzmann David D Cacoub Patrice P Saadoun David D
Journal of immunology (Baltimore, Md. : 1950) 20111114 12
Homeostasis of peripheral B cell subsets is disturbed during chronic hepatitis C virus (HCV) infection, leading to the occurrence of autoimmunity and B cell lymphoproliferation. However, mechanisms by which HCV causes lymphoproliferation remain controversial. We report in this article on the elevated number of clonal CD21(-/low)IgM(+)CD27(+) marginal zone (MZ)-like B cells, which correlates with autoimmunity and lymphoproliferation in HCV patients. We found an increase in autoreactive BCRs using ...[more]