The microRNA-205 is correlated to metastatic potential of 21T series: a breast cancer progression model
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ABSTRACT: To gain insights into the mechanisms involved in breast cancer progression we conducted a microRNA global expression analysis on a 21T series of cell lines obtained from the same patient during different stages of breast cancer progression. These stages are represented by cell lines derived from normal epithelial (16N), atypical ductal hyperplasia (21PT), primary in situ ductal carcinoma (21NT) and pleural effusion of a lung metastasis (21MT-1 and 21MT-2). In a global microRNA expression analysis, miR-205 was the only miRNA to display an important downregulation in the metastatic cell lines (21MT-1; 21MT-2) when compared to the non-invasive cells (21PT and 21NT). The lower amounts of miR-205 found also correlated with high histological grades biopsies and with higher invasion rates in a Boyden chamber assay. This work pinpoints miR-205 as a potential player in breast tumor invasiveness. These experiments are conducted as 2 replicates.
ORGANISM(S): Homo sapiens
SUBMITTER: Philippe Dessen
PROVIDER: E-MTAB-5239 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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