Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Laser Capture Microdissection and RNA Sequencing Human Adamantinomatous Craniopharyngioma


ABSTRACT: Laser capture microdissection of cluster cells, palisading epithelium and glial tissue from 2 cases of human adamantinomatous craniopharyngioma. 1 case performed in duplicate.

INSTRUMENT(S): Illumina MiSeq

ORGANISM(S): Homo sapiens

SUBMITTER: John Apps 

PROVIDER: E-MTAB-5266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2- cells in a paracrine manner. Here, we uncover the mechanisms underly  ...[more]

Publication: 1/2

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