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Laser Capture Microdissection and RNA Sequencing Human Adamantinomatous Craniopharyngioma

ABSTRACT: Laser capture microdissection of cluster cells, palisading epithelium and glial tissue from 2 cases of human adamantinomatous craniopharyngioma. 1 case performed in duplicate.

INSTRUMENT(S): Illumina MiSeq

ORGANISM(S): Homo sapiens

SUBMITTER: John Apps

PROVIDER: E-MTAB-5266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.

Gonzalez-Meljem Jose Mario JM Haston Scott S Carreno Gabriela G Apps John R JR Pozzi Sara S Stache Christina C Kaushal Grace G Virasami Alex A Panousopoulos Leonidas L Mousavy-Gharavy Seyedeh Neda SN Guerrero Ana A Rashid Mamunur M Jani Nital N Goding Colin R CR Jacques Thomas S TS Adams David J DJ Gil Jesus J Andoniadou Cynthia L CL Martinez-Barbera Juan Pedro JP

Nature communications 20171128 1

Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2- cells in a paracrine manner. Here, we uncover the mechanisms underly ...[more]

PMID: 29180744

Publication: 1/2

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