Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina MiSeq
ORGANISM(S): Homo sapiens
SUBMITTER: John Apps
PROVIDER: E-MTAB-5266 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gonzalez-Meljem Jose Mario JM Haston Scott S Carreno Gabriela G Apps John R JR Pozzi Sara S Stache Christina C Kaushal Grace G Virasami Alex A Panousopoulos Leonidas L Mousavy-Gharavy Seyedeh Neda SN Guerrero Ana A Rashid Mamunur M Jani Nital N Goding Colin R CR Jacques Thomas S TS Adams David J DJ Gil Jesus J Andoniadou Cynthia L CL Martinez-Barbera Juan Pedro JP
Nature communications 20171128 1
Senescent cells may promote tumour progression through the activation of a senescence-associated secretory phenotype (SASP), whether these cells are capable of initiating tumourigenesis in vivo is not known. Expression of oncogenic β-catenin in Sox2+ young adult pituitary stem cells leads to formation of clusters of stem cells and induction of tumours resembling human adamantinomatous craniopharyngioma (ACP), derived from Sox2- cells in a paracrine manner. Here, we uncover the mechanisms underly ...[more]