COPD progression in C57l/6 mice in response to chronic exposure (up to 7 months) to conventional cigarette smoke or a prototype modified risk tobacco product (pMRTP) and the impact of cessation or switching to pMRTP after initial exposure to conventional cigarette smoke

ABSTRACT: Smoking of combustible cigarettes has a major impact on human health, so the tobacco industry is developing modified risk tobacco products (MRTP) to reduce this health risk. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the potential of such a prototype (pMRTP) to reduce health risk. We investigated physiological endpoints in parallel with transcriptomics, lipidomics, and proteomics profiles in mice exposed to conventional cigarette smoke (3R4F) or a pMRTP aerosol for up to 7 months. We also included a cessation group and a switching-to-pMRTP group (after 2 months of 3R4F exposure) in addition to the control (fresh air-exposed) group, to understand the potential risk reduction of switching to pMRTP compared with continuous 3R4F exposure. The present manuscript describes the study design, setup, and implementation, as well as the generation, processing, and quality control analysis of the toxicology and 'omics' datasets that are accessible in public repositories for further studies.

ORGANISM(S): Mus musculus

SUBMITTER: Vincenzo Belcastro 

PROVIDER: E-MTAB-5281 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress