Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression profiling of human tissues from obese patients

ABSTRACT: This experiment captures the expression profiling in obese with type 2 diabetes and non-diabetic patients, in relevant tissues from the disease: liver, subcutaneous and visceral adipose tissues, and whole blood. Samples were obtained during bariatric surgery and preserved in RNA later at -70 C until the nucleic acid extraction.

ORGANISM(S): Homo sapiens

SUBMITTER: Francisco Barajas

PROVIDER: E-MTAB-5288 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

DNA Methylation analysis of human tissues from obese patients

Project description:This experiment captures the DNA methylation in obese patients with type 2 diabetes in relevant tissues from the disease: liver, subcutaneous and visceral adipose tissues, and whole blood. Samples were obtained during bariatric surgery and preserved in RNAlater at -70 C in RNAlater, until the nucleic acid extraction.

2018-02-15 | E-MTAB-5291 | biostudies-arrayexpress

Transcriptome analysis of Brg1 deficient small intestinal epithelium in the context of normal and aberrant Wnt signalling

Project description:Brg1 has been reported to act as a trans-activator for the Wnt pathway by interacting with beta-catenin. Given this interaction and the crucial role Wnt signalling plays in the intestinal homeostasis, we aimed to investigate the effect of Brg1 loss on gene expression in normal and Wnt activated small intestinal epithelium. We used VillinCreERT2 Cre recombinase and loxP targeted allels of Brg1 and Apc to generate 4 cohorts of conditional knock-out mice: Cre-negative controls (n=4), Brg1 deficient (n=4), Apc deficient (n=3) and double Brg1-Apc deficient (n=4). All mice were induced by 4x80mg/kg daily injections of Tamoxifen. Epithelium enriched (gut scrapes) samples of small intestine (jejunum) were collected at day 4 post induction. Loss of Brg1 expression in the small intestinal epithelium at this time point was confirmed by immunohistochemistry.

2013-08-07 | E-GEOD-46129 | biostudies-arrayexpress

A non-coding RNA from a carcinogenic virus induces an inflammatory response to promote virus production in infected cells

Project description:Three independent B cell samples infected with either EBV M81 devoid of EBER1+2 or its revertant were subjected to a RNA microarray analysis. RNA was isolated from each sample with the TRIzol reagent and treated with DNase to remove any traces of genomic DNA. Samples were analyzed with the Illumina HT12 platform.

2019-07-06 | E-MTAB-8102 | biostudies-arrayexpress

Genome-wide analysis of gene expression in MDA-MB-231 breast cancer cells in response to conditional miRNA mediated BSP knockdown.

Project description:Our goal was to identify the genes, which are modulated following conditional BSP knockdown for 3 and 6 days. Thus, to elucidate the BSP relevance and to broaden the knowledge on the affected signalling pathways. Cell pellets were collected after 3 and 6 days of cultivating the cells in media with or without doxycycline. There were duplicated total RNA samples for each time interval and each condition.The mRNA expression of the in vitro miRNA treated cells was compared to the respective +dox control.

2014-02-28 | E-GEOD-55432 | biostudies-arrayexpress

Gene expression profiling of splenic monocytes from TCL1-AT mice and WT controls

Project description:Analysis of the effect of CLL development on differentation and gene expression of splenic monocytes. C57BL/6 mice were transplanted with murine CLL cells from Eµ-TCL1 mice and after 6 weeks total RNA was isolated from splenic monocytes from leukemic mice and matched WT controls.

2015-07-01 | E-GEOD-66858 | biostudies-arrayexpress

Gene expression profile in offspring born before vs. after maternal bariatric surgery

Project description:Evaluate differences in gene expression levels between offspring born after maternal bariatric surgery and their siblings born before surgery Offspring born after maternal bariatric surgery (AMS, N=23) vs. offspring born before maternal surgery (BMS, N=23)

2013-05-16 | E-GEOD-44407 | biostudies-arrayexpress

Gene expression profile in Lmna knockout mouse embryonic fibroblast

Project description:Alteration of gene expression profile due to Lmna knockout was studied in MEF. Total RNA obtained from Lmna +/+ MEF and Lmna -/- MEF were compared.

2012-06-18 | E-GEOD-38777 | biostudies-arrayexpress

Comparison of SSAT overexpressing mouse models

Project description:It has been shown that in a mouse model overexpressing spermidine/spermine N1-acetyltransferase (SSAT) in whole body the mice have improved glucose homeostasis, reduced white adipose tissue (WAT) mass and high basal metabolic rate. In this study we investigated the glucose and energy metabolism in another SSAT overexpressing mouse model (MT-SSAT) and in addition created a novel mouse model that has adipose tissue specific SSAT overexpression (aP2-SSAT) in order to elaborate the role of enhanced polyamine catabolism in WAT. In this experiment, gene expression profiles of WAT from wild type, SSAT, MT-SSAT and aP2-SSAT mice were studied.

2012-01-01 | E-MTAB-569 | biostudies-arrayexpress

An epigenetically distinct breast cancer cell subpopulation promotes collective invasion

Project description:A distinct highly invasive subpopulation was identified in breast cancer cell lines. The molecular characteristics of these cells was investigated, revealing a set of genes whose high expression confers the ability to invade. Total RNA isolated from the invasive subpopulation from 2 cells lines was compared to total RNA isolated from 2 noninvasive populations.

2014-06-19 | E-GEOD-58643 | biostudies-arrayexpress

Control of breast cancer cell migration by a p63-regulated signaling network (RNA)

Project description:Through analysis of a high-content screen we discovered that mir-203 can impair cell migration by suppressing p63 expression. We further determined that p63 promotes motility by inducing the expression of multiple target genes. Total RNA isolated from cell lines with different rated of motility was compared.

2014-10-22 | E-GEOD-62568 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data