Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500
ORGANISM(S): Homo sapiens
SUBMITTER: Sebastiaan Meijsing
PROVIDER: E-MTAB-5352 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Thormann Verena V Rothkegel Maika C MC Schöpflin Robert R Glaser Laura V LV Djuric Petar P Li Na N Chung Ho-Ryun HR Schwahn Kevin K Vingron Martin M Meijsing Sebastiaan H SH
Nucleic acids research 20180401 6
Genomic binding of transcription factors, like the glucocorticoid receptor (GR), is linked to the regulation of genes. However, as we show here, GR binding is a poor predictor of GR-dependent gene regulation even when taking the 3D organization of the genome into account. To connect GR binding sites to the regulation of genes in the endogenous genomic context, we turned to genome editing. By deleting GR binding sites, individually or in combination, we uncovered how cooperative interactions betw ...[more]