Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Mus musculus
SUBMITTER: Timothy Pullen
PROVIDER: E-MTAB-5708 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mitchell Ryan K RK Nguyen-Tu Marie-Sophie MS Chabosseau Pauline P Callingham Rebecca M RM Pullen Timothy J TJ Cheung Rebecca R Leclerc Isabelle I Hodson David J DJ Rutter Guy A GA
The Journal of biological chemistry 20170404 21
Heterozygous mutations in the human paired box gene <i>PAX6</i> lead to impaired glucose tolerance. Although embryonic deletion of the <i>Pax6</i> gene in mice leads to loss of most pancreatic islet cell types, the functional consequences of <i>Pax6</i> loss in adults are poorly defined. Here we developed a mouse line in which <i>Pax6</i> was selectively inactivated in β cells by crossing animals with floxed <i>Pax6</i> alleles to mice expressing the inducible Pdx1CreERT transgene. <i>Pax6</i> d ...[more]