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Requirement for the Mediator kinase module for activation of super-enhancer associated genes in colon cancer cells

ABSTRACT: RNA sequencing of HCT116 colon cancer cells following single and combined depletions of Mediator kinase module subunits CDK8, CDK19, MED12, MED13 and MED13L and the BET family protein BRD4. The results provide insight into the shared and specific functions of kinase module subunits and BRD4 in regulation of expression of transcriptional programs including genes associated with cancer acquired super-enhancers.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Eva Domenech-Moreno

PROVIDER: E-MTAB-5873 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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