Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Bacillus subtilis treated with plectasin


ABSTRACT: transriptional profiling of Bacillus subtilis treated with Plectasin

ORGANISM(S): Bacillus subtilis strain 168

SUBMITTER: Allan Nielsen 

PROVIDER: E-MTAB-60 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Host defense peptides such as defensins are components of innate immunity and have retained antibiotic activity throughout evolution. Their activity is thought to be due to amphipathic structures, which enable binding and disruption of microbial cytoplasmic membranes. Contrary to this, we show that plectasin, a fungal defensin, acts by directly binding the bacterial cell-wall precursor Lipid II. A wide range of genetic and biochemical approaches identify cell-wall biosynthesis as the pathway tar  ...[more]

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