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MicroRNA array profiling on human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin

ABSTRACT: Cardiomyocytes derived from human pluripotent stem cells were exposed to the cardiotoxic drug Doxorubicin in order to assess the utility of this cell system as a model for drug-induced cardiotoxicity. Cells are exposed to different concentrations of doxorubicin for up to 48 hours followed by a 12 days recovery period.

ORGANISM(S): Homo sapiens

SUBMITTER: Jane Synnergren

PROVIDER: E-MTAB-6052 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.

Holmgren Gustav G Synnergren Jane J Andersson Christian X CX Lindahl Anders A Sartipy Peter P

Toxicology in vitro : an international journal published in association with BIBRA 20160406

Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic drugs used for treatment of a variety of cancers, including solid tumors, leukemia, lymphomas, and breast cancer. The successful use of doxorubicin has, however, been hampered by severe cardiotoxic side-effects. In order to prevent or reverse negative side-effects of doxorubicin, it is important to find early biomarkers of heart injury and drug-induced cardiotoxicity. The high stability under extreme cond ...[more]

PMID: 27033315

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