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Unknown,Transcriptomics,Genomics,Proteomics

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Vallier D4.5 SB

ABSTRACT: Gene expression profiling experiment to identify genes up and down regulated by the presence of Activin during pancreatic specification.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Trotter

PROVIDER: E-MTAB-606 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors.

Brown Stephanie S Teo Adrian A Pauklin Siim S Hannan Nicholas N Cho Candy H-H CH Lim Bing B Vardy Leah L Dunn N Ray NR Trotter Matthew M Pedersen Roger R Vallier Ludovic L

Stem cells (Dayton, Ohio) 20110801 8

Activin/Nodal signaling is necessary to maintain pluripotency of human embryonic stem cells (hESCs) and to induce their differentiation toward endoderm. However, the mechanisms by which Activin/Nodal signaling achieves these opposite functions remain unclear. To unravel these mechanisms, we examined the transcriptional network controlled in hESCs by Smad2 and Smad3, which represent the direct effectors of Activin/Nodal signaling. These analyses reveal that Smad2/3 participate in the control of t ...[more]

PMID: 21630377

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