RNA-seq of human U2OS cells depleted of NUAK1 by shRNA compared to control
Ontology highlight
ABSTRACT:
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Homo sapiens
SUBMITTER: Daniel Murphy
PROVIDER: E-MTAB-6244 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.
Port Jennifer J Muthalagu Nathiya N Raja Meera M Ceteci Fatih F Monteverde Tiziana T Kruspig Björn B Hedley Ann A Kalna Gabriela G Lilla Sergio S Neilson Lisa L Brucoli Martina M Gyuraszova Katarina K Tait-Mulder Jacqueline J Mezna Mokdad M Svambaryte Silvija S Bryson Amy A Sumpton David D McVie Allan A Nixon Colin C Drysdale Martin M Esumi Hiroyasu H Murray Graeme I GI Sansom Owen J OJ Zanivan Sara R SR Murphy Daniel J DJ
Cancer discovery 20180302 5
Exploiting oxidative stress has recently emerged as a plausible strategy for treatment of human cancer, and antioxidant defenses are implicated in resistance to chemotherapy and radiotherapy. Targeted suppression of antioxidant defenses could thus broadly improve therapeutic outcomes. Here, we identify the AMPK-related kinase NUAK1 as a key component of the antioxidant stress response pathway and reveal a specific requirement for this role of NUAK1 in colorectal cancer. We show that NUAK1 is act ...[more]
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