Transcription profiling of human cluster headache patients peripheral blood on Affymetrix arrays vs. controls

ABSTRACT: Background - Cluster headache (CH) is a primary neurovascular headache disorder characterized by attacks of excruciating pain accompanied by ipsilateral autonomic symptoms. CH pathophysiology is presumed to involve an activation of hypothalamic and trigeminovascular systems, but inflammation and immunological mechanisms have also been hypothesized to be of importance. Objective - A pilot study to identify differentially expressed genes during different clinical phases of CH, assuming that changes of pathophysiological importance would also be seen in peripheral venous blood. Methods - Blood samples were drawn at 3 consecutive occasions from 3 episodic CH patients: during attacks,between attacks and in remission, and at 1 occasion from 3 matchedcontrols. Global gene expression was analyzed

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER:  

PROVIDER: E-MTAB-631 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress