Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer IIx
ORGANISM(S): Mus musculus
SUBMITTER: Daniel Murphy
PROVIDER: E-MTAB-6432 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Neidler Sarah S Kruspig Björn B Hewit Kay K Monteverde Tiziana T Gyuraszova Katarina K Braun Attila A Clark William W James Daniel D Hedley Ann A Nieswandt Bernhard B Shanks Emma E Dick Craig C Murphy Daniel J DJ
Cancers 20190429 5
Inducible genetically defined mouse models of cancer uniquely facilitate the investigation of early events in cancer progression, however, there are valid concerns about the ability of such models to faithfully recapitulate human disease. We developed an inducible mouse model of progressive lung adenocarcinoma (LuAd) that combines sporadic activation of oncogenic KRas<sup>G12D</sup> with modest overexpression of c-MYC (KM model). Histological examination revealed a highly reproducible spontaneou ...[more]