Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Progression of KRas^G12D;Rosa26-MYC tumours to invasive disease


ABSTRACT: The aim of the study was to investigate gene expression tumour progression of KRas*/MYC driven lung tumours from adenocarcinoma in situ to invasive disease.

INSTRUMENT(S): Illumina Genome Analyzer IIx

ORGANISM(S): Mus musculus

SUBMITTER: Daniel Murphy 

PROVIDER: E-MTAB-6432 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma.

Neidler Sarah S   Kruspig Björn B   Hewit Kay K   Monteverde Tiziana T   Gyuraszova Katarina K   Braun Attila A   Clark William W   James Daniel D   Hedley Ann A   Nieswandt Bernhard B   Shanks Emma E   Dick Craig C   Murphy Daniel J DJ  

Cancers 20190429 5


Inducible genetically defined mouse models of cancer uniquely facilitate the investigation of early events in cancer progression, however, there are valid concerns about the ability of such models to faithfully recapitulate human disease. We developed an inducible mouse model of progressive lung adenocarcinoma (LuAd) that combines sporadic activation of oncogenic KRas<sup>G12D</sup> with modest overexpression of c-MYC (KM model). Histological examination revealed a highly reproducible spontaneou  ...[more]

Publication: 1/2

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