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RNA-seq analysis of anti-malarial drug chemotherapy of murine experimental Cerebral Malaria (ECM)

ABSTRACT: Cerebral Malaria (HCM) is a serious neurological complication caused by Plasmodium falciparum infection. Currently the only treatment for HCM is the provision of anti-malarial drugs; however, such treatment by itself often fails to prevent death or development of neurological sequelae. To identify new potential adjunct treatments for HCM, we performed a non-biased whole brain transcriptomic time-course analysis of anti-malarial drug chemotherapy of murine experimental CM (ECM).

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Leo Zeef

PROVIDER: E-MTAB-6474 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.

Strangward Patrick P Haley Michael J MJ Albornoz Manuel G MG Barrington Jack J Shaw Tovah T Dookie Rebecca R Zeef Leo L Baker Syed M SM Winter Emma E Tzeng Te-Chen TC Golenbock Douglas T DT Cruickshank Sheena M SM Allan Stuart M SM Craig Alister A Liew Foo Y FY Brough David D Couper Kevin N KN

Proceedings of the National Academy of Sciences of the United States of America 20180628 28

Cerebral malaria (CM) is a serious neurological complication caused by <i>Plasmodium falciparum</i> infection. Currently, the only treatment for CM is the provision of antimalarial drugs; however, such treatment by itself often fails to prevent death or development of neurological sequelae. To identify potential improved treatments for CM, we performed a nonbiased whole-brain transcriptomic time-course analysis of antimalarial drug chemotherapy of murine experimental CM (ECM). Bioinformatics ana ...[more]

PMID: 29954866

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