Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 3000
ORGANISM(S): Mus musculus
SUBMITTER: Nils-Göran Larsson
PROVIDER: E-MTAB-6533 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kauppila Johanna H K JHK Bonekamp Nina A NA Mourier Arnaud A Isokallio Marita A MA Just Alexandra A Kauppila Timo E S TES Stewart James B JB Larsson Nils-Göran NG
Nucleic acids research 20180701 13
Mitochondrial DNA (mtDNA) mutations become more prevalent with age and are postulated to contribute to the ageing process. Point mutations of mtDNA have been suggested to originate from two main sources, i.e. replicative errors and oxidative damage, but the contribution of each of these processes is much discussed. To elucidate the origin of mtDNA mutations, we measured point mutation load in mice with deficient mitochondrial base-excision repair (BER) caused by knockout alleles preventing mitoc ...[more]