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A new ALK isoform transported by extracellular vesicles confers drug resistance to vemurafenib in A375 melanoma cells

ABSTRACT: Despite the successful use of drugs targeting the MAPK signaling pathway and immunotherapy in melanoma, the majority of patients with metastatic disease still undergo disease progression indicating a gradual development of therapy resistance. In the present study, microarray analyses were performed on BRAF inhibitor sensitive melanoma cells A375 and corresponding vemurafenib (PLX4032) - resistant cells A375_X1 to describe changes in the transcriptome that might play a role in drug resistance. For each cell line the microarray experiment was performed in duplicates.

ORGANISM(S): Homo sapiens

SUBMITTER: Giulia Cesi

PROVIDER: E-MTAB-6596 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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