Unknown,Transcriptomics,Genomics,Proteomics

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Expression analysis of the auditory cortex after various behavior treatments


ABSTRACT: Auditory cued fear conditioning is a widely used behavioral paradigm to investigate associative learning and memory formation. During conditioning, an animal learns that a particular auditory stimulus predicts an aversive stimulus, a foot shock. When later confronted again with this conditional auditory stimulus rodents typically respond with a cessation of movement. The purpose of this study was to analyze the effects of auditory fear conditioning on gene expression in the auditory cortex in a number of different paradigms that control for the effect of several behavioral factors. The different paradigms were M-^SpairedM-^T were the sound and the shock are paired so that the mouse associates the tone with the noxious stimulus the shock, M-^SsoundM-^T were only the sound was presented, M-^SshockM-^T were only the shock was presented, M-^SunpairedM-^T were the sound and the shock were presented one minute apart so that the mouse cannot form an association between the sound and the shock, M-^ScontextM-^T were no sounds or shocks were presented but the mouse was in the behavior chamber and M-^SHCM-^T were the mouse was taken directly from the cage.

ORGANISM(S): Mus musculus

SUBMITTER: Manuel Peter 

PROVIDER: E-MTAB-661 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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