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Whole transcriptome assay of human urinary bladder cancer tumor samples from the central part and invasive front of individual tumors

ABSTRACT: The experiment aimed to illuminate differences at the transcriptional level in whole tumor samples between the invasive front and central part of tumors. Samples were collected at the initial transurethral resection of the tumor.

ORGANISM(S): Homo sapiens

SUBMITTER: Malin Winerdal

PROVIDER: E-MTAB-6624 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Urinary Bladder Cancer Tregs Suppress MMP2 and Potentially Regulate Invasiveness.

Winerdal Malin E ME Krantz David D Hartana Ciputra A CA Zirakzadeh Ali A AA Linton Ludvig L Bergman Emma A EA Rosenblatt Robert R Vasko Janos J Alamdari Farhood F Hansson Johan J Holmström Benny B Johansson Markus M Winerdal Max M Marits Per P Sherif Amir A Winqvist Ola O

Cancer immunology research 20180327 5

Regulatory T cells (Treg) have long been considered one-sided suppressors of antitumor immune responses and hence associated with poor patient outcome in cancer. However, evidence is mounting of a paradoxical positive prognostic effect of Tregs on certain malignancies, including urinary bladder cancer (UBC). This discrepancy has partly been attributed to the shear misidentification of Tregs, but also to the inflammatory profile of the tumor. Our aim was to determine whether tumor-infiltrating Fo ...[more]

PMID: 29588320

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