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Unknown,Transcriptomics,Genomics,Proteomics

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ScRNA-seq of Mus musculus subcutaneous Lin- cells derived from the subcutaneous adipose stromal vascular fraction

ABSTRACT: We used the resolving power of single-cell transcriptional profiling to molecularly characterize the mouse adipose stem and progenitor cell-enriched, subcutaneous adipose stromal vascular fraction. We molecularly assessed CD45- CD31- SVF cells using the 10x Genomics Chromium (10x) platform.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Mus musculus

SUBMITTER: Petra Catalina Schwalie

PROVIDER: E-MTAB-6677 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A stromal cell population that inhibits adipogenesis in mammalian fat depots.

Schwalie Petra C PC Dong Hua H Zachara Magda M Russeil Julie J Alpern Daniel D Akchiche Nassila N Caprara Christian C Sun Wenfei W Schlaudraff Kai-Uwe KU Soldati Gianni G Wolfrum Christian C Deplancke Bart B

Nature 20180620 7712

Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities1,2. Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes3-14, our understanding of their in vivo origin and properties is incomplete2,15,16. This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots17, which has proven difficult to ...[more]

PMID: 29925944

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