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Expression profiling of K-Ras-driven lung carcinogenesis upon the genetic absence of Enpp2 from pulmonary cells

ABSTRACT: To decipher the role of Enpp2 (ATX) in lung carcinogenesis, a replication-deficient adenovirus expressing the cre recombinase (Ad-Cre) was administered intratracheally to K-rasLSL-G12D/+Enpp2n/n mice, as well as to control K-rasLSL-G12D/+ littermates, thus removing the synthetic stop element (LSL; lox-stop-lox) and allowing the expression of the oncogene and the overtime development of LC, as well as the genetic deletion of enpp2 in the corresponding mice. RNA was extracted from 3 lung samples per genotype and hybriidized to Affy microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Vassilis Aidinis

PROVIDER: E-MTAB-6706 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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