Transcription profiling by array of eWAT from CD1 WT and Irx5-KO mice fed a high fat diet
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Simon Dankel
PROVIDER: E-MTAB-6726 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity.
Bjune Jan-Inge JI Haugen Christine C Gudbrandsen Oddrun O Nordbø Ole P OP Nielsen Hans J HJ Våge Villy V Njølstad Pål R PR Sagen Jørn V JV Dankel Simon N SN Mellgren Gunnar G
International journal of obesity (2005) 20181211 11
<h4>Objective</h4>A causal obesity risk variant in the FTO locus was recently shown to inhibit adipocyte thermogenesis via increased adipose expression of the homeobox transcription factors IRX3 and IRX5. However, causal effects of IRX5 on fat storage remain to be shown in vivo, and discovery of downstream mediators may open new therapeutic avenues.<h4>Methods</h4>17 WT and 13 Irx5 knockout (KO) mice were fed low-fat control (Ctr) or high-fat (HF) diet for 10 weeks. Body weight, energy intake an ...[more]
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