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The Variantome of the malaria parasite Plasmodium falciparum.

ABSTRACT: We compared transcript levels at several points along the asexual blood cycle between 21 P. falciparum lines. These 21 parasite lines are organized in 4 sets of parasite lines, with all parasite lines within a set sharing a clonal origin. We compared transcript levels within each set. We also performed comparative genome hybridization (CGH) for all 21 parasite lines.

ORGANISM(S): Plasmodium falciparum

SUBMITTER: Alfred Cortes

PROVIDER: E-MTAB-673 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional variation in the malaria parasite Plasmodium falciparum.

Rovira-Graells Núria N Gupta Archna P AP Planet Evarist E Crowley Valerie M VM Mok Sachel S Ribas de Pouplana Lluís L Preiser Peter R PR Bozdech Zbynek Z Cortés Alfred A

Genome research 20120313 5

Malaria genetic variation has been extensively characterized, but the level of epigenetic plasticity remains largely unexplored. Here we provide a comprehensive characterization of transcriptional variation in the most lethal malaria parasite, Plasmodium falciparum, based on highly accurate transcriptional analysis of isogenic parasite lines grown under homogeneous conditions. This analysis revealed extensive transcriptional heterogeneity within genetically homogeneous clonal parasite population ...[more]

PMID: 22415456

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