Whole-genome methylation analysis (450k) of school aged children prenatally exposed to alcohol vs controls
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ABSTRACT: We tested a hypothesis that prenatal alcohol exposure may lead to epigenetic alterations to the DNA resulting in attentional and cognitive alterations of the children. 6-9 year old children school children of the Franconian Cognition and Emotion Studies (FRANCES) cohort which were tested for an objective marker of PAE, ethyl glucuronide (EtG) in meconium at birth. 32 newborns were found to be exposed to alcohol with a threshold above 30 ng/g (EtG+) but without a FAS diagnosis. DNA for methylation analysis was extracted from buccal cells, DNA methylation was analyzed using the Infinium Human Methylation 450K BeadChip array (Illumina).
ORGANISM(S): Homo sapiens
SUBMITTER: Stefan Frey
PROVIDER: E-MTAB-6730 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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