Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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RNA-seq of Plasmodium vivax derived from clinical isolates


ABSTRACT: This project contains RNA-sequencing reads of Plasmodium vivax derived directly from clinical patients. Here, we aim to characterize the gene expression patterns in patients with various parasite compositions. Patients (n=10) were recruited from two malaria endemic areas in Thailand. Ten RNA samples were treated with DNase, followed by Epicentre Globin-Zero Gold kit to deplete rRNA and globin transcript. The RNA-seq libraries were sequenced on an Illumina HiSeq4000 platform to generate approximately 60 million paired-end reads of 150 bp for each sample.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Chaturong Putaporntip 

PROVIDER: E-MTAB-6753 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Clinical expression and antigenic profiles of a Plasmodium vivax vaccine candidate: merozoite surface protein 7 (PvMSP-7).

Cheng Chew Weng CW   Jongwutiwes Somchai S   Putaporntip Chaturong C   Jackson Andrew P AP  

Malaria journal 20190613 1


<h4>Background</h4>Vivax malaria is the predominant form of malaria outside Africa, affecting about 14 million people worldwide, with about 2.5 billion people exposed. Development of a Plasmodium vivax vaccine is a priority, and merozoite surface protein 7 (MSP-7) has been proposed as a plausible candidate. The P. vivax genome contains 12 MSP-7 genes, which contribute to erythrocyte invasion during blood-stage infection. Previous analysis of MSP-7 sequence diversity suggested that not all paralo  ...[more]

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