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Transcriptional profiling of the tuberculin skin test in patients with active and latent tuberculosis

ABSTRACT: Transcriptome at the site of a 48 hour tuberculin skin test (TST) and saline injection from patients with active TB disease and latent TB infection

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Gabriele Pollara

PROVIDER: E-MTAB-6816 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease.

Pollara Gabriele G Turner Carolin T CT Rosenheim Joshua J Chandran Aneesh A Bell Lucy C K LCK Khan Ayesha A Patel Amit A Peralta Luis Felipe LF Folino Anna A Akarca Ayse A Venturini Cristina C Baker Tina T Ecker Simone S Ricciardolo Fabio L M FLM Marafioti Teresa T Ugarte-Gil Cesar C Moore David A J DAJ Chain Benjamin M BM Tomlinson Gillian S GS Noursadeghi Mahdad M

Science translational medicine 20210501 592

Host immune responses at the site of <i>Mycobacterium tuberculosis</i> infection can mediate pathogenesis of tuberculosis (TB) and onward transmission of infection. We hypothesized that pathological immune responses would be enriched at the site of host-pathogen interactions modeled by a standardized tuberculin skin test (TST) challenge in patients with active TB compared to those without disease, and interrogated immune responses by genome-wide transcriptional profiling. We show exaggerated int ...[more]

PMID: 33952677

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