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Gene-expression profile of human embryonic germ cells

ABSTRACT: Gene-expression profile of human embryonic germ cells (EGCs), primordial germ cells (PGCs), embryonal carcinoma cells (ECCs), pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs)

ORGANISM(S): Homo sapiens

SUBMITTER: Intidhar Labidi-Galy

PROVIDER: E-MTAB-6851 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells.

Pashai Nikta N Hao Haiping H Hao Haiping H All Angelo A Gupta Siddharth S Chaerkady Raghothama R De Los Angeles Alejandro A Gearhart John D JD Kerr Candace L CL

PloS one 20120621 6

Human embryonic germ cells (EGCs) provide a powerful model for identifying molecules involved in the pluripotent state when compared to their progenitors, primordial germ cells (PGCs), and other pluripotent stem cells. Microarray and Principal Component Analysis (PCA) reveals for the first time that human EGCs possess a transcription profile distinct from PGCs and other pluripotent stem cells. Validation with qRT-PCR confirms that human EGCs and PGCs express many pluripotency-associated genes bu ...[more]

PMID: 22737227

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