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Transcription profiling by array of effects of TMEM70 downregulation on gene expression in liver of spontaneously hypertensive rats

ABSTRACT: TMEM70 (transmembrane protein 70), a 21 kDa protein localized in the inner mitochondrial membrane, facilitates the biogenesis of mammalian F1Fo ATP synthase. Mutations of Tmem70 gene represent most frequent cause of isolated deficiency of human ATP synthase resulting in a severe, often fatal neonatal mitochondrial encephalo-cardiomyopathy. Contrary to humans, targeting of Tmem70 results in embryonic lethality in both mice and rats. In the current study, we tested effects of downregulation of the Tmem70 gene on gene transcription in the SHR (spontaneously hypertensive rat) heterozygotes.We performed gene expression profiling in the liver and found differentially expressed genes involved in innate imunity (RT1-T24-4, RT1-N3, RT1-CE5, Cd36, Marco, Socs3) and regulation of oxidative phosphorylation (Cdk1, Ccna2, Slc25a3).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Michal Pravenec

PROVIDER: E-MTAB-6887 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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