Dataset Information
RNA-Seq of human breast cancer cells MCF7 and LCC2 treated with Tamoxifen; EPZ or DMSO
Ontology highlight
ABSTRACT:
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Homo sapiens
SUBMITTER: Giorgio Giurato
PROVIDER: E-MTAB-6892 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells.
Science advances 20190206 2
Breast cancer (BC) resistance to endocrine therapy results from constitutively active or aberrant estrogen receptor α (ERα) signaling, and ways to block ERα pathway in these tumors are sought after. We identified the H3K79 methyltransferase DOT1L as a novel cofactor of ERα in BC cell chromatin, where the two proteins colocalize to regulate estrogen target gene transcription. DOT1L blockade reduces proliferation of hormone-responsive BC cells in vivo and in vitro, consequent to cell cycle arrest ...[more]
