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Copy number profiling via ArrayCGH on high grade serous epithelial ovarian cancer samples from multiple biopsies

ABSTRACT: We performed Array CGH on 25 patients with high grade serous epithelial ovarian cancer (HGS-EOC): each of this had multiple biopsies taken at the moment of the surgery in different anatomical sites, and 18 had also temporal biopsies taken after several cycles of chemotherapy. Blood was used as control. The experiment was performed to identify genomic alterations that can be used to classify the disease, going beyond the individual tumor heterogeneity.

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Mannarino

PROVIDER: E-MTAB-6900 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Multisite analysis of high-grade serous epithelial ovarian cancers identifies genomic regions of focal and recurrent copy number alteration in 3q26.2 and 8q24.3.

Ballabio Sara S Craparotta Ilaria I Paracchini Lara L Mannarino Laura L Corso Silvia S Pezzotta Maria Grazia MG Vescio Martina M Fruscio Robert R Romualdi Chiara C Dainese Emanuele E Ceppi Lorenzo L Calura Enrica E Pileggi Silvana S Siravegna Giulia G Pattini Linda L Martini Paolo P Delle Marchette Martina M Mangioni Costantino C Ardizzoia Antonio A Pellegrino Antonio A Landoni Fabio F D'Incalci Maurizio M Beltrame Luca L Marchini Sergio S

International journal of cancer 20190426 10

High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the genome of all tumor cells across the different anatomical districts. This knowledge is the first step to clarify those molecular determinants that characterize the tumor biology of H ...[more]

PMID: 30892690

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