Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of IMR-5/75 neuroblastoma cell line treated with JQ1, THZ1 or combination against untreated controls

ABSTRACT: RNA-seq upon JQ1 (1 uM), THZ1 (35 nM), UT (untreated) or combination treatment in the neuroblastoma cell line IMR-5/75. Analysis was performed 10h upon treament. Four biological replicates per condition.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Bieke Decaesteker

PROVIDER: E-MTAB-7025 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

RNA-seq of IMR-5/75 neuroblastoma cell line upon TBX2 and/or MYCN knockdown

Project description:RNA-seq upon TBX2, MYCN or combination of TBX2 and MYCN knockdown in the neuroblastoma cell line IMR-5/75. Cells were transduced with two different shRNAs (shTBX2_2 and shTBX2_4) targeting TBX2 and a non-targeting control (NTC), and selected with puromycin. Cells were treated with doxycycline for shMYCN induction (with DOX or not). Analysis was performed three days upon TBX2 knockdown and two days upon MYCN knockdown, including six biological replicates per condition.

2018-08-16 | E-MTAB-6568 | biostudies-arrayexpress

ATAC-seq in neuroblastoma IMR-32 cell line

Project description:ATAC-seq to define open chromatin in the neuroblastoma IMR-32 cell line.

2018-08-16 | E-MTAB-6562 | biostudies-arrayexpress

ATAC-seq in IMR-32, CLB-GA and SH-EP neuroblastoma cell lines.

Project description:ATAC-seq to define open and closed chromatin in the human IMR-32, CLB-GA and SH-EP neuroblastoma cell lines in an untreated way.

2023-02-23 | E-MTAB-12588 | biostudies-arrayexpress

RNA-seq of human IMR-32 neuroblastoma cell line with SOX11 knockdown as compared to control

Project description:RNA-seq to define downstream targets of adrenergic SOX11 upon knockdown using 4 siRNAs against SOX11 in the SOX11 expressing adrenergic cell line IMR-32. Analysis was performed 48h upon after nucleofections, control samples are treated with siNTC (non-targeted control). 4 biological replicates were used.

2022-12-13 | E-MTAB-9340 | biostudies-arrayexpress

ChIP-seq of neuroblastoma IMR-32, CLB-GA, NGP, IMR-5/75, GI-M-EN, CHP-212, and IMR-5 cell lines to identify TBX2, MYCN, H3K27ac, H3K4me1 and H3K4me3 binding sites

Project description:ChIP-seq to define bindings sites for TBX2, MYCN, H3K27ac, H3K4me1, H3K4me3 and Input in the cell lines IMR-32, CLB-GA, NGP, IMR-5/75, GI-M-EN, CHP-212, and IMR-5.

2018-10-16 | E-MTAB-6570 | biostudies-arrayexpress

RNA-seq of CLB-GA neuroblastoma cell line upon TBX2 knockdown

Project description:RNA-seq upon TBX2 knockdown in the neuroblastoma cell line CLB-GA. Cells were transduced with two different shRNAs (sh#2 and sh#4) targeting TBX2 and a non-targeting control (NTC), and selected with puromycin. Analysis was performed seven days upon TBX2 knockdown, including three biological replicates per condition.

2018-08-16 | E-MTAB-6567 | biostudies-arrayexpress

Investigating the effect of CDK inhibition in EML4-ALK cells by ChIP-seq for RNA polymerase II.

Project description:RNA polymerase II ChIP-seq in human H3122 CrizR1 cells treated with DMSO, 200nM alvocidib or 100nM THZ1.

2020-05-13 | E-MTAB-8380 | biostudies-arrayexpress

Targeted sequencing of Cerberus T-cells (Cb-STs) and pentavalent specific T-cells (Penta-STs) targeting CMV, EBV, BKV, adenovirus and Aspergillus fumigatus

Project description:Amplicon-based sequencing of Pentavalent specific T-cells (unedited pathogen-specific T-cells targeting CMV, EBV, BKV, adenovirus and Aspergillus fumigatus) and Cerberus T-cells (CRISPR/Cas9 edited Glucocorticoid-resistant T-cells targeting CMV, EBV, BKV, adenovirus and Aspergillus fumigatus) for off-target sites prediction.

2021-01-14 | E-MTAB-9968 | biostudies-arrayexpress

ATAC-seq of human CLB-GA neuroblastoma cell line with SOX11 knockdown as compared to control

Project description:ATAC-seq to define open and closed chromatin in the human CLG-GA neuroblastoma cell line upon SOX11 knockdown using siRNAs. Analysis was performed 48h upon after nucleofection, control samples are treated with siNTC (non-targeting control). 2 biological replicates were used.

2023-12-30 | E-MTAB-9463 | biostudies-arrayexpress

Targeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition [Gene Expression]

Project description:Global gene expression after CDK7 inhibition by THZ1 Global gene expression after genetic knockdown or overexpression of MYCN

2014-11-21 | E-GEOD-62724 | biostudies-arrayexpress