Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Genome-Scale interrogation of the colorectal cancer methylome by Illumina HumanMethylation450 array

ABSTRACT: Colorectal cancer is an epigenetically heterogeneous disease, the extent to which is unclear. In this study we interrogate the methylome of 216 unselected colorectal cancers using Illumina HumanMethylation450 arrays, and correlate these data with transcript profiles and exome sequencing analysis to elucidate the degree of epigenetic dysregulation in colorectal cancers.

ORGANISM(S): Homo sapiens

SUBMITTER: Lochlan Fennell

PROVIDER: E-MTAB-7036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas.

Fennell Lochlan L Dumenil Troy T Wockner Leesa L Hartel Gunter G Nones Katia K Bond Catherine C Borowsky Jennifer J Liu Cheng C McKeone Diane D Bowdler Lisa L Montgomery Grant G Klein Kerenaftali K Hoffmann Isabell I Patch Ann-Marie AM Kazakoff Stephen S Pearson John J Waddell Nicola N Wirapati Pratyaksha P Lochhead Paul P Imamura Yu Y Ogino Shuji S Shao Renfu R Tejpar Sabine S Leggett Barbara B Whitehall Vicki V

Cellular and molecular gastroenterology and hepatology 20190405 2

<h4>Background & aims</h4>Colorectal cancer is an epigenetically heterogeneous disease, however, the extent and spectrum of the CpG island methylator phenotype (CIMP) is not clear.<h4>Methods</h4>Genome-scale methylation and transcript expression were measured by DNA Methylation and RNA expression microarray in 216 unselected colorectal cancers, and findings were validated using The Cancer Genome Atlas 450K and RNA sequencing data. Mutations in epigenetic regulators were assessed using CIMP-subt ...[more]

PMID: 30954552

Dataset Information

Genome-Scale interrogation of the colorectal cancer methylome by Illumina HumanMethylation450 array

Publications

Integrative Genome-Scale DNA Methylation Analysis of a Large and Unselected Cohort Reveals 5 Distinct Subtypes of Colorectal Adenocarcinomas.

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