Transcriptome differences in HCC infiltrated CD8+ T cells in effector and exhaustion state
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ABSTRACT: CD8+ T cells isolated from HCC tissue were divided into three groups: PD1-TIM3- CD8+ TILs, exhibiting full effector function; PD1-intTIM3+ CD8+ TILs, exhibiting partial exhaustion; and PD1-hiTIM3+ CD8+ TILs, exhibiting severe exhaustion, as reflected by the differences in their ability to produce effector cytokines respectively. Transcriptome sequence analysis was performed to investigate the gene expression profile was performed.
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Xiaochen Wang
PROVIDER: E-MTAB-7278 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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