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MiRNA expression in Follicular Thyroid Adenomas and Carcinoma

ABSTRACT: The experiment was performed to identify differentially expressed microRNAs in follicular thyroid carcinoma and adenoma vs. normal thyroid tissue to explore possible common features in the proliferation stages. Furthermore comparisons between the carcinoma and adenoma were performed to search for distinct microRNAs that could be used in a classification model.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Maria Rossing

PROVIDER: E-MTAB-736 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Down-regulation of microRNAs controlling tumourigenic factors in follicular thyroid carcinoma.

Rossing Maria M Borup Rehannah R Henao Ricardo R Winther Ole O Vikesaa Jonas J Niazi Omid O Godballe Christian C Krogdahl Annelise A Glud Martin M Hjort-Sørensen Christian C Kiss Katalin K Bennedbæk Finn Noe FN Nielsen Finn Cilius FC

Journal of molecular endocrinology 20120125 1

The molecular determinants of thyroid follicular nodules are incompletely understood and assessment of malignancy is a diagnostic challenge. Since microRNA (miRNA) analyses could provide new leads to malignant progression, we characterised the global miRNA expression in follicular adenoma (FA) and follicular carcinoma (FC). Comparison of carcinoma and adenoma with normal thyroid revealed 150 and 107 differentially expressed miRNAs respectively. Most miRNAs were down-regulated and especially miR- ...[more]

PMID: 22049245

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