Comparative analysis of the molecular mechanisms of melanocyte regeneration and melanoma using the zebrafish model

ABSTRACT: Zebrafish have the ability to regenerate many organs and tissues including the melanocytes which are elements of the skin. RNA sequencing (RNA-Seq) is a high-throughput sequencing method facilitating transcript identification and quantification of gene expression in a precise manner. The development of RNA-Seq technologies and their extensive data-analysis methods make an investigation of regulatory genes and functional gene annotations possible under specific conditions. Here, we aim to perform large-scale comparative deep transcriptome profiling of regeneration versus cancer in the following two cellular contexts: The skin melanocytes, which can substantially regenerate in mammals and melanoma which is the type of cancer that begins in the melanocytes.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Danio rerio

SUBMITTER: Yeliz Demirci 

PROVIDER: E-MTAB-7464 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress