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Whole tissue RNA-seq of human melanoma metastasis of patients prior and on anti-CD20 antibody therapy

ABSTRACT: Eliminating B cells through anti-CD20 antibody led to a drastic reshaping of the inflammatory tumor microenvironment. This included a profound reduction of T cells, endothelial cells, monocytes and fibroblasts. The results of this study are therefore the first evidence in human that B cells are required to sustain the inflammatory tumor microenvironment.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Johannes Griss

PROVIDER: E-MTAB-7473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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