Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias


ABSTRACT: Combined all trans retinoic acid (ATRA) / arsenic regimen cures virtually all acute promyelocytic leukemi (APL) patients. However, APL is often associated with activating FLT3-internal tandem duplication (ITD) mutation and the molecular bases for this effect remain unknown. Using mouse APL models, we demonstrate the FLT3-ITD severely blunts ATRA response.

ORGANISM(S): Mus musculus

SUBMITTER: Hugues De Thé 

PROVIDER: E-MTAB-7566 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2005-10-06 | GSE2550 | GEO
2010-04-03 | E-GEOD-14016 | biostudies-arrayexpress
2008-05-07 | E-GEOD-2550 | biostudies-arrayexpress
2009-04-01 | GSE14016 | GEO
2009-12-17 | E-GEOD-18886 | biostudies-arrayexpress
2023-07-20 | PXD038638 | Pride
2010-04-08 | E-GEOD-12766 | biostudies-arrayexpress
2017-09-08 | GSE86526 | GEO
2019-07-09 | GSE133925 | GEO
2020-09-02 | PXD009423 | Pride