Genome-wide analysis of low dose bisphenol-A (BPA) exposure in human prostate cells

ABSTRACT: Endocrine disrupting compounds (EDCs) have the potential to cause adverse effects on wildlife and human health. Two important EDCs are the synthetic estrogen 17a-ethynylestradiol (EE2) and bisphenol A (BPA) both of which are xenoestrogens (XEs) as they bind the estrogen receptor and disrupt estrogen physiology in mammals and other vertebrates. In recent years the influence of XEs on oncogenes, specifically in relation to breast and prostate cancer has been the subject of considerable study. In this study healthy primary human prostate epithelial cells (PrECs) were exposed to environmentally relevant concentrations of BPA (5nM and 25nM BPA) and interrogated using a whole genome microarray. Microarray data were analyzed using the Pipeline for Integrated Microarray Expression and Normalizat

ORGANISM(S): Homo sapiens

SUBMITTER: Gary Hardiman 

PROVIDER: E-MTAB-7576 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress