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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse brain infected with prions in eight mouse-prion strain combinations in a systems approach to the study of prion disease

ABSTRACT: Prions cause transmissible neurodegenerative diseases and replicate by conformational conversion of normal, benign forms of prion protein (PrPC) to disease-causing PrPSc isoforms. A systems approach to disease postulates that disease arises from the pathological perturbation (genetic and/or environmental) of one or more biological networks in the relevant organ. In this regard, we tracked global (all mRNA transcripts) gene expression in the brains of eight distinct mouse strain-prion strain combinations at 8 - 10 time points throughout the progression of the disease to capture the effects of prion strain, host genetics, and PrP concentration on disease incubation time. Data are also available from http://prion.systemsbiology.net

ORGANISM(S): Mus musculus

SUBMITTER: Nils Gehlenborg

PROVIDER: E-MTAB-76 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A systems approach to prion disease.

Hwang Daehee D Lee Inyoul Y IY Yoo Hyuntae H Gehlenborg Nils N Cho Ji-Hoon JH Petritis Brianne B Baxter David D Pitstick Rose R Young Rebecca R Spicer Doug D Price Nathan D ND Hohmann John G JG Dearmond Stephen J SJ Carlson George A GA Hood Leroy E LE

Molecular systems biology 20090324

Prions cause transmissible neurodegenerative diseases and replicate by conformational conversion of normal benign forms of prion protein (PrP(C)) to disease-causing PrP(Sc) isoforms. A systems approach to disease postulates that disease arises from perturbation of biological networks in the relevant organ. We tracked global gene expression in the brains of eight distinct mouse strain-prion strain combinations throughout the progression of the disease to capture the effects of prion strain, host ...[more]

PMID: 19308092

Publication: 1/2

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