Expression-analysis of human peripheral blood mononuclear cells (PBMC) cocultivated with RT-4 cells transduced with a trivalent adenoviral vector (Im02) for expression of 4-1BBL, IL-12 and IL-2
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ABSTRACT: The trivalent adenoviral vector Im02 encodes the cDNAs for human 4-1BBL, IL-12 and IL-2. This vector was designed to change the immune tumor microenvironment. At the outset, we investigated the immune stimulating effect of Im02 transduced urothelial cancer cells (RT-4). Human PBMCs of a healthy donor were cocultured with these cells in a time series experiment. An adenoviral vector without expression cassette and cultivation without a vector were applied as control.
ORGANISM(S): Homo sapiens
SUBMITTER: Carolin Biermann-Fleischhauer
PROVIDER: E-MTAB-7615 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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