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Time series of murine lungs after flu infection

ABSTRACT: Time course data from influenza A-infected mice were collected for up to 60 days after infection to monitor gene expression profiles of the host. Whole lungs of individual mice were harvested from three independent infection experiments and at least three biological replicates were taken for a single time point. Mock-infected mice served as controls. Early after infection, the activation of RIG-I and interferon pathways as well as the up-regulation of chemokine and cytokine expression revealed the innate immune response phase which was closely correlated with the presence of infectious virus. Subsequently, viral clearance was initiated by the onset of T cell infiltration. In the late phase of infection, the formation of tertiary lymphoid tissues, bronchus-associated lymphoid tissue (BALT), was observed. The formation of BALT resulted in permanent steady-state changes of the lung transcriptome.

ORGANISM(S): Mus musculus

DISEASE(S): influenza A

SUBMITTER: Claudia Pommerenke

PROVIDER: E-MTAB-764 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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