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Immunologic pathways in protective versus maladaptive host responses to attenuated and pathogenic strains of Mycoplasma gallisepticum

ABSTRACT: The goal of this study was to compare the host's response (chicken tracheal epithelium) to laboratory attenuated vaccine versus pathogenic strains of M. gallisepticum

INSTRUMENT(S): UCHC CAM HPC cluster, NextSeq 500

ORGANISM(S): Gallus gallus

SUBMITTER: Edan Tulman

PROVIDER: E-MTAB-7675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Immunologic Pathways in Protective versus Maladaptive Host Responses to Attenuated and Pathogenic Strains of Mycoplasma gallisepticum.

Beaudet Jessica J Tulman Edan R ER Pflaum Katherine K Canter Jessica A JA Silbart Lawrence K LK Geary Steven J SJ

Infection and immunity 20190221 3

Mycoplasmas are small bacterial commensals or pathogens that commonly colonize host mucosal tissues and avoid rapid clearance, in part by stimulating inflammatory, immunopathogenic responses. We previously characterized a wide array of transcriptomic perturbations in avian host tracheal mucosae infected with virulent, immunopathologic <i>Mycoplasma gallisepticum</i>; however, mechanisms delineating these from protective responses, such as those induced upon vaccination, have not been thoroughly ...[more]

PMID: 30559221

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