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Transcription profiling of liver from rats treated with perfluorododecanoic acid

ABSTRACT: Micorarray analysis of gene expression in PFDoA dosed rats

ORGANISM(S): Rattus norvegicus

SUBMITTER: Lina Ding

PROVIDER: E-MTAB-77 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Systems biological responses to chronic perfluorododecanoic acid exposure by integrated metabonomic and transcriptomic studies.

Ding Lina L Hao Fuhua F Shi Zhimin Z Wang Yulan Y Zhang Hongxia H Tang Huiru H Dai Jiayin J

Journal of proteome research 20090601 6

Perfluorocarboxylic acids (PFCAs) have been widely used in consumer and industrial products, such as food packaging, and found in the blood of both humans and wildlife. Although studies showed a high tendency toward biological accumulation and a variety of toxic effects for PFCAs, the mechanistic aspects of their toxicity remain unknown. In present study, we investigated the dosage-dependent metabonomic and transcriptomic responses of male rats to the exposure to perfluorododecanoic acid (PFDoA) ...[more]

PMID: 19378957

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