Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500
ORGANISM(S): Mus musculus
SUBMITTER: Jules GILET
PROVIDER: E-MTAB-7704 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Legoux François F Gilet Jules J Procopio Emanuele E Echasserieau Klara K Bernardeau Karine K Lantz Olivier O
Nature immunology 20190820 9
Mucosal-associated invariant T cells (MAIT cells) recognize the microbial metabolite 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU) presented by the MHC class Ib molecule, MR1. MAIT cells acquire effector functions during thymic development, but the mechanisms involved are unclear. Here we used single-cell RNA-sequencing to characterize the developmental path of 5-OP-RU-specific thymocytes. In addition to the known MAIT1 and MAIT17 effector subsets selected on bone-marrow-derived hem ...[more]