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Transcriptional disorganization of fibroblasts is a hallmark of the aging heart

ABSTRACT: Transcriptomes of hearts of 12 weeks and 18 months old mice by single-nucleus RNA-sequencing

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Ramon Oliveira Vidal

PROVIDER: E-MTAB-7869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart.

Vidal Ramon R Wagner Julian Uwe Gabriel JUG Braeuning Caroline C Fischer Cornelius C Patrick Ralph R Tombor Lukas L Muhly-Reinholz Marion M John David D Kliem Magdalena M Conrad Thomas T Guimarães-Camboa Nuno N Harvey Richard R Dimmeler Stefanie S Sauer Sascha S

JCI insight 20191114 22

Aging is a major risk factor for cardiovascular disease. Although the impact of aging has been extensively studied, little is known regarding the aging processes in cells of the heart. Here we analyzed the transcriptomes of hearts of 12-week-old and 18-month-old mice by single-nucleus RNA-sequencing. Among all cell types, aged fibroblasts showed most significant differential gene expression, increased RNA dynamics, and network entropy. Aged fibroblasts exhibited significantly changed expression ...[more]

PMID: 31723062

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