Dual-mechanism ERK1/2 inhibitors exploit a distinct binding mode to block phosphorylation and nuclear accumulation of ERK1/2, resulting in enhanced potency

ABSTRACT: Here we have characterized the MoA of Erk inhibitors in terms of Erk1/2 signalling, gene expression and antiproliferative efficacy in BRAF and RAS mutant cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Harpreet Saini 

PROVIDER: E-MTAB-7959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress